Both Real Madrid and FC Barcelona look set to lose key defenders for at least a month, with right-back Dani Carvajal sidelined for Real Madrid and central defender Inigo Martinez out for Barca.
The second round of the Spanish Copa del Rey knockout competition gets underway on Tuesday, with sides from La Liga looking to progress into the round of 32 against lower league opposition.
The highly-anticipated Serie A fixture between Napoli and Inter Milan turned out to be a lopsided affair, as visitors Inter emerged 3-0 winners with three different players on target.
Real Madrid took advantage of the fact that Girona don't play Athletic Bilbao until Monday night to return to the top of the La Liga table with a 3-0 win away to Cadiz.
Real Madrid continued to assure the future of their promising players, with the confirmation on Thursday that Uruguayan midfielder Fede Valverde has extended his contract until the end of June 2029.
England international midfielder Jude Bellingham is doubtful for Real Madrid's Champions League game at home to Sporting Braga on Wednesday after suffering a dislocated shoulder.